It depends.
You do not need your personal computer's Globus endpoint set to high assurance for the purposes of transferring data to Soteria using our UA HPC HIPAA Filesystems endpoint. HIPAA requires data transfer auditing. We log transfers on our DTN that use the HIPAA endpoint, regardless of the client's managed status.
If you are working with another institution/endpoint that only allows connections from high assurance endpoints, then you must enable High Assurance during your Globus Personal Connect configuration process. This requires that you are added to our Globus subscription which can be done by opening a support ticket to request help from our consultants. Your endpoint must be set to public to allow us to add you. Once you have been added, you may set your endpoint to private.